- Osteocalcin and analogs thereof. Benjamin, D: May 25, 2014 US 62/002,403
This is a patent on analogs of osteocalcin and its fragments optimized for improved pharmocokinetics, decreased immunogenicity, and enhanced efficacy for use as an antinflammatory in trauma, spinal degenerative disease and rheumatoid arthritis, and in diabetes.
Publications
- Lange DJ, Andersen, PM, Marklund, S, Benjamin D: Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: A phase I pilot study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2013; 14: 199–204
- Benjamin D: Identification of pyrimethamine as an inhibitor of SOD-1 expression at the protein level. In preparation.
- Patterson-Buckendahl, P, Sowinska A, Yee S, Patel D, Pagkalinawan S, Shahid M, Shah A, Franz C, Benjamin D, Pohorecky LA: Decreased sensory responses in osteocalcin null mutant mice imply neuropeptide function. Cell Mol Neurobiol. 2012 Jul;32(5):879-89.
Presentations
- Benjamin, D, Sun, DM, Vatson, J, Pohorecky LA, Patterson-Buckendahl, P. Inflammatory gene expression following spinal cord injury is reduced in osteocalcin null mutant mice. Soc. for Neuroscienci. Abstr. November 2014.
- Patterson-Buckendahl, P, Benjamin, D. Use of MC3T3 cells for native high-level secretion of carboxylated mouse osteocalcin. American Society for Bone and Mineral Research Annual Meeting Abstracts, Sept. 2014
- Patterson-Buckendahl, P;; Sowinska, A; Patel, J; Lu, M; Pagkalinawan, S; Sun, DM; Benjamin, D: Osteocalcin reduces bone loss but delays recovery in mice following spinal cord injury. Soc. for Neuroscienci. Abstr. November 2012.
- Benjamin, D: Progesterone and analogs decrease SOD1 expression in the cell: Application to familial ALS. ESHG, June, 2011
- Benjamin D, Franz C, Buckendahl P.: Osteocalcin gene and protein expression in rat neural tissues. J Bone Miner Res 25 (Suppl 1, 2010)